abstract：:We investigated the influence of oxygenation of in vitro lung preparation on the pulmonary vascular reactivity. Small pulmonary vessels isolated from adult male Wistar rats exposed for 4 days to hypoxia (F(iO2) = 0.1, group CH) were compared with those of normoxic controls (group N). The bath in the chamber of small v...

journal_title：Physiological research

authors： Zaloudíková M,Vízek M,Herget J

更新日期：2009-01-01 00:00:00

abstract：:Gastrointestinal hormones play an important role in the neuroendocrine regulation of food intake and postprandial satiety. Ghrelin is a 28-amino acid orexigenic peptide produced mainly by the stomach that is involved in both the long-term regulation of body weight and the short-term regulation of postprandial satiety....

journal_title：Physiological research

authors： Dostálová I,Haluzík M

更新日期：2009-01-01 00:00:00

abstract：:Reduced physical activity and abundant energy intake are two most common factors leading to uncontrolled body weight gain. But these factors are not under entire internal consciousness control; they are also partially genetically determined and are affected by for example food marketing practices. In addition to these...

journal_title：Physiological research

authors： Hubácek JA

更新日期：2009-01-01 00:00:00

abstract：:Hepcidin is a key regulator of iron metabolism and a mediator of anemia in inflammation. Recent in vitro studies recognized prohepcidin as a type II acute phase protein regulating via interleukin-6. The aim of the present study was to investigate the time course of plasma prohepcidin after a large cardiac surgery in r...

journal_title：Physiological research

authors： Maruna P,Lindner J,Kunstýr J,Plocová K,Hubácek J

更新日期：2009-01-01 00:00:00

abstract：:Neuroprotective effects of estrogens and progesterone have been widely studied in various experimental models. The present study was designed to compare possible neuroprotective effects of 17alpha-estradiol, 17beta-estradiol, and progesterone on oxidative stress in rats subjected to global cerebral ischemia. Global ce...

journal_title：Physiological research

authors： Ozacmak VH,Sayan H

更新日期：2009-01-01 00:00:00

abstract：:Rhythmic daily changes in the Na,K-ATPase activity have been previously described for rat kidney cortex, showing two peaks: at 0900 h and 2100 h, and two valleys: at 1500 h and 0100 h -0300 h. The oscillations in Na,K-ATPase activity are produced by an inhibitor, which binds the enzyme and is present in the rat blood ...

journal_title：Physiological research

authors： Reyes A,Galindo MM,García L,Segura-Pena D,Caruso-Neves C,Eblen-Zajjur A,Proverbio T,Marín R,Proverbio F

更新日期：2009-01-01 00:00:00

abstract：:Atherogenesis involves the migration of leukocytes into vascular subendothelial space, a process mediated by endothelial and leukocyte cell adhesion molecules. Endothelial molecules are assessed indirectly via serum levels, but leukocyte molecules can be assessed directly. We have therefore hypothesized that leukocyte...

journal_title：Physiological research

authors： Stulc T,Vrablík M,Kasalová Z,Marinov I,Svobodová H,Ceska R

更新日期：2008-01-01 00:00:00

abstract：:The effects of selenium (Se) on antioxidant defense system in liver and kidneys of rats with cadmium (Cd)-induced toxicity were examined. Cd exposure (15 mg Cd/kg b.m./day as CdCl(2) for 4 weeks) resulted in increased lipid peroxidation (LP) in both organs (p<0.005 and p<0.01). Vitamin C (Vit C) was decreased in the l...

journal_title：Physiological research

authors： Ognjanović BI,Marković SD,Pavlović SZ,Zikić RV,Stajn AS,Saicić ZS

更新日期：2008-01-01 00:00:00

abstract：:The purpose of the study was to check whether hypoxia of corneal tissue increases the collagenolytic activity due to release of reactive oxygen and nitrogen species. Rats were exposed to hypoxia 10% O(2) for 4, 14, and 21 days. The radical tissue injury was measured by the level of nitrotyrosine and changes in the lip...

journal_title：Physiological research

authors： Mahelková G,Korynta J,Moravová A,Novotná J,Vytásek R,Wilhelm J

更新日期：2008-01-01 00:00:00

abstract：:The effect of ethanol on the structural development of the central nervous system was studied in offspring of Wistar rats, drinking 20 % ethanol during pregnancy and till the 28th day of their postnatal life. The structural changes in the hippocampus and dentate gyrus were analyzed at the age of 18, 35 and 90 days. A ...

journal_title：Physiological research

authors： Milotová M,Riljak V,Jandová K,Bortelová J,Maresová D,Pokorný J,Langmeier M

更新日期：2008-01-01 00:00:00

abstract：:The aim of present study was to investigate functional and physical alterations in membranes of heart mitochondria that are associated with remodeling of these organelles in acute phase of streptozotocin-induced diabetes and to elucidate the role of these changes in adaptation of the heart to acute streptozotocin-indu...

journal_title：Physiological research

authors： Ferko M,Habodászová D,Waczulíková I,Mujkosová J,Kucharská J,Sikurová L,Ziegelhoffer B,Styk J,Ziegelhoffer A

更新日期：2008-01-01 00:00:00

abstract：:Exposure to hyperbaric oxygen leads to increased amount of reactive oxygen species (ROS) that are derived from various sources. After the discovery that ROS can function as signaling molecules, the idea of ROS being hazardous to biological tissues has been challenged. The aim of this study was to examine the changes i...

journal_title：Physiological research

authors： Gürdöl F,Cimşit M,Oner-Iyidoğan Y,Körpinar S,Yalçinkaya S,Koçak H

更新日期：2008-01-01 00:00:00

abstract：:Neonatal exposure to hyperoxia alters lung development in mice. We tested if retinoic acid (RA) treatment is capable to affect lung development after hyperoxic injury and to maintain structural integrity of lung. The gene of vascular endothelial growth factor A (VEGF-A) is one of the RA-responsive genes. Newborn BALB/...

journal_title：Physiological research

authors： Zimová-Herknerová M,Myslivecek J,Potmesil P

更新日期：2008-01-01 00:00:00

abstract：:Experimental and epidemiological studies suggest that calcium intake is inversely related to weight gain. Calcium of dairy origin has been shown to be more effective in promoting weight loss. However, clinical studies yielded controversial results concerning the role of calcium intake in weight change. The aim of this...

journal_title：Physiological research

authors： Kabrnová-Hlavatá K,Hainer V,Gojová M,Hlavatý P,Kopský V,Nedvídková J,Kunesová M,Parízková J,Wagenknecht M,Hill M,Drbohlav J

更新日期：2008-01-01 00:00:00

abstract：:The objective of the present experiment was to assess the involvement of small intestine in expression of susceptibility or resistance to the high-fat/high-energy diet. The investigation was carried out in adult male Sprague-Dawley rats fed either standard laboratory diet (3.2 kcal/g, 9.5 % fat) or high-fat (HF) diet ...

journal_title：Physiological research

authors： Sefcíková Z,Hájek T,Lenhardt L,Racek L,Mozes S

更新日期：2008-01-01 00:00:00

abstract：:The pathological potential of glial cells was recognized already by Rudolf Virchow, Santiago Ramon y Cajal and Pio Del Rio-Ortega. Many functions and roles performed by astroglia in the healthy brain determine their involvement in brain diseases; as indeed any kind of brain insult does affect astrocytes, and their per...

journal_title：Physiological research

authors： Chvátal A,Anderová M,Neprasová H,Prajerová I,Benesová J,Butenko O,Verkhratsky A

更新日期：2008-01-01 00:00:00

abstract：:Hindlimb unweighting (HU) leads to capillary regression in skeletal muscle. However, the molecular mechanism(s) remains to be elucidated. To gain insight into the regulation of this process, we investigated gene expression of hypoxia-inducible factor-1alpha (HIF-1alpha)vascular endothelial growth factor (VEGF), angiop...

journal_title：Physiological research

authors： Wagatsuma A

更新日期：2008-01-01 00:00:00

abstract：:An important mechanism underlying cochlear hair cell (HC) susceptibility to hypoxia/ischemia is the influx of Ca(2+). Two main ATP-dependent mechanisms contribute to maintaining low Ca(2+) levels: uptake of Ca(2+) into intracellular stores via smooth endoplasmic reticulum calcium ATPase (SERCA) and extrusion of Ca(2+)...

journal_title：Physiological research

authors： Amarjargal N,Mazurek B,Haupt H,Andreeva N,Fuchs J,Gross J

更新日期：2008-01-01 00:00:00

abstract：:This study aimed to examine relationships between DHEA(S), anthropometric parameters, oral glucose tolerance test derived data and lipid spectra in a Czech non-diabetic population. 380 healthy volunteers both with and without a family history of diabetes type 2 (DM2) were enrolled into the study (women: n=235, age 28....

journal_title：Physiological research

authors： Bendlová B,Vrbíková J,Hill M,Vanková M,Lukásová P,Vcelák J,Vejrazková D,Dvoráková K,Hampl R,Vondra K,Stárka L

更新日期：2008-01-01 00:00:00

abstract：:Osteoporotic fractures are the result of low density and especially inferior bone quality (microarchitecture) caused by both internal (genes, hormones) and external (life style) influences. Bone mechanosensors are extremely important for the overall integrity of the skeleton, because in response to mechanical load the...

journal_title：Physiological research

authors： Zofková I

更新日期：2008-01-01 00:00:00

abstract：:The present study investigated the effects of head cooling during endurance cycling on performance and the serotonergic neuroendocrine response to exercise in the heat. Subjects exercised at 75 % VO(2max) to volitional fatigue on a cycle ergometer at an ambient temperature of 29+/-1.0 degrees C, with a relative humidi...

journal_title：Physiological research

authors： Ansley L,Marvin G,Sharma A,Kendall MJ,Jones DA,Bridge MW

更新日期：2008-01-01 00:00:00

abstract：:The mitochondrial DNA (mtDNA) amount in cells as the basis for mitochondrial energy generating system, which produces ATP, plays an important role in the fetal development and postnatal morbidity. Isolated human cord blood leukocytes (HCBL) contribute very little to the overall metabolic turnover, but they may serve a...

journal_title：Physiological research

authors： Pejznochová M,Tesarová M,Honzík T,Hansíková H,Magner M,Zeman J

更新日期：2008-01-01 00:00:00

abstract：:The effect of oral supplementation with glycosaminoglycans (GAG) and radical scavengers (vitamin E/selenium) on the regeneration of osteochondral defects was investigated in rabbits. After introduction of defined osteochondral defects in the knee joint, groups of ten animals were given a GAG/vitamin E/selenium mixture...

journal_title：Physiological research

authors： Handl M,Amler E,Bräun K,Holzheu J,Trc T,Imhoff AB,Lytvynets A,Filová E,Kolárová H,Kotyk A,Martínek V

更新日期：2007-01-01 00:00:00

abstract：:Metabolic consequences of direct muscle trauma are insufficiently defined. Their effects on the ubiquitin-proteasome pathway (UPP) of protein degradation in human skeletal muscles are as yet unknown. Thus, we investigated whether the UPP is involved in the metabolic response evoked in directly traumatized human skelet...

journal_title：Physiological research

authors： Seiffert M,Gosenca D,Ponelies N,Ising N,Patel MB,Obertacke U,Majetschak M

更新日期：2007-01-01 00:00:00

abstract：:The aim of this study was to determine the effect of chronic crowding on the cardiovascular system of Wistar-Kyoto (WKY) rats. Rats were randomly divided into the control (480 cm(2) per rat) or crowded (200 cm(2) per rat) group for eight weeks. Body weight, blood pressure (BP), heart rate and plasma nitrate/nitrite le...

journal_title：Physiological research

authors： Bernátová I,Púzserová A,Navarová J,Csizmadiová Z,Zeman M

更新日期：2007-01-01 00:00:00

abstract：:Aldosterone receptor antagonist, spironolactone, has been shown to prevent remodeling of the heart in several models of left ventricular hypertrophy. The aim of the present study was to determine whether the treatment with spironolactone can prevent hypertension, reduction of tissue nitric oxide synthase activity and ...

journal_title：Physiological research

authors： Simko F,Matúsková J,Lupták I,Pincíková T,Krajcírovicová K,Stvrtina S,Pomsár J,Pelouch V,Paulis L,Pechánová O

更新日期：2007-01-01 00:00:00

abstract：:An oxidant/antioxidant imbalance is thought to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). We hypothesized that antioxidant capacity reflected by erythrocyte glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) activities, and serum levels of the l...

journal_title：Physiological research

authors： Kluchová Z,Petrásová D,Joppa P,Dorková Z,Tkácová R

更新日期：2007-01-01 00:00:00

abstract：:We sought to examine the association between maternal erythrocyte omega-3, omega-6 and trans fatty acids and risk of preeclampsia. We conducted a case-control study of 170 women with proteinuric, pregnancy-induced hypertension and 185 normotensive pregnant women who delivered at Harare Maternity Hospital, Harare, Zimb...

journal_title：Physiological research

authors： Mahomed K,Williams MA,King IB,Mudzamiri S,Woelk GB

更新日期：2007-01-01 00:00:00

abstract：:The potential of novel scaffold containing sodium hyaluronate, type I collagen, and fibrin was investigated in the regeneration of osteochondral defects in miniature pigs. Both autologous chondrocyte-seeded scaffolds and non-seeded scaffolds were implanted into two defects located in the non-weight-bearing zone of the...

journal_title：Physiological research

authors： Filová E,Rampichová M,Handl M,Lytvynets A,Halouzka R,Usvald D,Hlucilová J,Procházka R,Dezortová M,Rolencová E,Kostáková E,Trc T,Stastný E,Kolácná L,Hájek M,Motlík J,Amler E

更新日期：2007-01-01 00:00:00

abstract：:Whole blood surface tension of 15 healthy subjects recorded by the ring method was investigated in the temperature range from 20 to 40 degrees C. The surface tension omega as a function of temperature t ( degrees C) is described by an equation of linear regression as omega(t) = (-0.473 t + 70.105) x 10(-3) N/m. Blood ...

journal_title：Physiological research

authors： Rosina J,Kvasnák E,Suta D,Kolárová H,Málek J,Krajci L

更新日期：2007-01-01 00:00:00

abstract：:We studied the effect of thiazide-like diuretic--indapamide on fibrosis development in the left ventricle of young spontaneously hypertensive rats (SHR) and assessed the involvement of nitric oxide in this process. Six-week-old male SHR were treated with indapamide (1 mg/kg/day) for six weeks. Age-matched SHR were use...

journal_title：Physiological research

authors： Janega P,Kojsová S,Jendeková L,Babál P,Pechánová O

更新日期：2007-01-01 00:00:00

abstract：:Certain liver metabolic diseases point to the presence of disturbances in glycogen deposition. Epinephrine raises the cAMP level that activates protein kinase A leading to the activation of phosphorylase and glycogen breakdown. In the present report, we sought to investigate whether NO is produced during adrenoceptor ...

journal_title：Physiological research

authors： Hodis J,Kutinová-Canová N,Potmesil P,Kameníková L,Kmonícková E,Zídek Z,Farghali H

更新日期：2007-01-01 00:00:00

abstract：:Extensive osteolysis adjacent to orthopedic implants is often associated with wear particles of prosthetic material. The activation of the RANKL/RANK/OPG system is considered to be a likely cause of periprosthetic osteolysis leading to implant failure. The aim of this study was to examine the possible correlation betw...

journal_title：Physiological research

authors： Veigl D,Niederlová J,Krystůfková O

更新日期：2007-01-01 00:00:00

abstract：:The effect of increased coronary flow on transmural ventricular repolarization was investigated in six pentobabital-anesthetized sheep. Fresh blood at 10 ml/min was injected into the left circumflex coronary artery (LCX) in addition to the normal coronary flow. Unipolar electrocardiograms were simultaneously registere...

journal_title：Physiological research

authors： Zhang YZ,He B,Wang LX

更新日期：2007-01-01 00:00:00

abstract：:We studied the psychophysiology of soluble intercellular adhesion molecule-1 (sICAM-1) in 25 apparently healthy middle-aged men who underwent an acute psychosocial stressor three times with one week apart. Measures of the biological stress response were obtained at week one and three. The magnitude of the sICAM-1 stre...

journal_title：Physiological research

authors： von Känel R,Preckel D,Kudielka BM,Fischer JE

更新日期：2007-01-01 00:00:00

abstract：:Using non-cholesterol sterols investigation several authors postulated a hypothesis that in the metabolic syndrome cholesterol endogenous synthesis is increased and its absorption decreased. Our study is the first attempt to evaluate the direct relation of cholesterol metabolism to the principal pathogenetic phenomeno...

journal_title：Physiological research

authors： Smahelová A,Hyspler R,Haas T

更新日期：2007-01-01 00:00:00

abstract：:Leptin and adiponectin, two adipocytokines, may work together in regulating energy homeostasis and insulin action. Leptin gene expression has been investigated in term placental tissue complicated by gestational diabetes mellitus (GDM), but never in conjunction with all isoforms of the leptin receptor (LEPR A-D), or w...

journal_title：Physiological research

authors： Meller M,Qiu C,Vadachkoria S,Abetew DF,Luthy DA,Williams MA

更新日期：2006-01-01 00:00:00

abstract：:Eukaryotic cytochrome c oxidase (CcO), the terminal component of the mitochondrial electron transport chain is a heterooligomeric complex that belongs to the superfamily of heme-copper containing terminal oxidases. The enzyme, composed of both mitochondrially and nuclear encoded subunits, is embedded in the inner mito...

journal_title：Physiological research

authors： Stiburek L,Hansikova H,Tesarova M,Cerna L,Zeman J

更新日期：2006-01-01 00:00:00

abstract：:Experiments were performed in C57BL/6J male mice to determine the effects of acetylcholinesterase (AChE) inhibitor pyridostigmine bromide (PB) and stress on cardiovascular function, structure, and apoptosis. Mice were studied for seven days under the following conditions: Controls (osmotic minipump with saline), PB (1...

journal_title：Physiological research

authors： Bernátová I,Babál P,Grubbs RD,Morris M

更新日期：2006-01-01 00:00:00

abstract：:We investigated how postural responses to galvanic vestibular stimulation were affected by standing on a translating support surface and by somatosensory loss due to diabetic neuropathy. We tested the hypothesis that an unstable surface and somatosensory loss can result in an increase of vestibulospinal sensitivity. B...

journal_title：Physiological research

authors： Hlavacka F,Horak FB

更新日期：2006-01-01 00:00:00